Advances in Enzyme Regulation

Advances in Enzyme Regulation


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Volume 42 lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies. This volume contains papers of 25 outstanding scientists working at the cutting edge of metabolic regulation. Much of the volume focuses on novel aspects of signal transduction with an emphasis on nuclear expression.

One of the highlights of this volume is the Special Symposium Lecture. This was given for 15 years by Sir Hans A. Krebs who passed away 20 years ago. It was now given by Professor Sir Hans L. Kornberg, University Professor at Boston University.

These volumes continue to be a source of information and inspiration and a laboratory and advanced teaching companion. The immediate and long-range significance of these cutting-edge presentations of these novel topics should be immediately clear to the reader.

Product Details

ISBN-13: 9780080418629
Publisher: Elsevier Science & Technology Books
Publication date: 05/28/1992
Pages: 392

Table of Contents

Session headings and papers: Multidrug Resistance and Enzymology. Differences in the properties of mammalian ribonucleotide reductase toward its substrates (J.G. Cory et al.). The function of the multidrug resistance protein in drug conjugate transport and hepatobiliary excretion (D. Keppler et al.). Signal Transduction-Targeted Anticancer Action. Current issues in the regulation of signal transduction (G. Weber et al.). Mechanism and structure based inhibitors of phospholipase C enzymes (M.F. Roberts et al.). Genetic Regulation of Enzymic Activities. Inosine monophosphate dehydrogenase expression: transcriptional regulation of the type I and type II genes (B.S. Mitchell et al.). Regulation of the human bilirubin UDP-glucuronosyltransferase gene (C.H. Brierley et al.). Control Mechanisms of Inositol Lipid Metabolism. Inositol lipid cycle and autonomous nuclear signalling (L. Cocco et al.). The phosphatidylinositol 4-phosphate 5-kinase family (R.A. Anderson et al.). Regulation of Thymidylate Synthase and Gene Expression. The role of thymidylate synthase in cellular regulation (E. Chu, C.J. Allegra). rTS gene expression is associated with altered cell sensitivity to thymidylate synthase inhibitors (B.J. Dolnick et al.). Nutritional and Hormonal Regulation of Enzymic Activities. Hormonal regulation of pyruvate dehydrogenase complex (R.M. Denton et al.). Regulation of lipogenic enyzme expression by glucose in liver and adipose tissue: a review of the potential cellular and molecular mechanisms (F. Foufelle et al.). Control Mechanisms inSignal Transduction by Drugs. A novel action of lithium: stimulation of glutamate release and inositol 1,4,5-trisphosphate accumulation via activation of the n-methyl-d-aspartate receptor in monkey and mouse cerebral cortex slices (L.E. Hokin et al.). Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers (G.V. Los et al.). Anticancer Action of Enzyme Inhibitors and Gene Products. Inhibition of experimental metastasis by enzyme inhibitors from microorganisms and plants (K. Umezawa). The retinoblastoma gene product is a negative modulator of the apoptotic pathway (G. Fan, C.J. Steer). Regulation Through Proteolytic Enzymes. The role of proteolytic enzymes in the deposition of amyloid proteins (A. Sato et al.). Cellular proteases involved in the pathogenicity of enveloped animal viruses. Human immunodeficiency virus. Influenza virus A and sendai virus (H. Kido et al.). Physiological Control Mechanisms. Influence of bile salts on hepatic mdr2 p-glycoprotein expression (C.M.G. Frijters et al.). The role of dietary folate in modulation of folate receptor expression. Folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol (L.G. Mendelsohn et al.). Special Symposium Lecture: H.H. Grunicke. Cellular signalling as a target in cancer chemotherapy. Phospholipid analogues as inhibitors of mitogenic signal transduction (H.H. Grunicke et al.). Author Index. Subject Index.

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