Lon Chaney Sr. plays David Webster, an honest lawyer unjustly sentenced to a 15-year jail term. Upon his release, Webster adopts a disguise so that he can get even with Fletcher Burton (Ralph Lewis), the man who framed him. The ex-convict is compelled to alter his plans when Burton's son (Jack Mulhall) falls in love with Webster's daughter (Edith Roberts). Noah Beery Sr. tries manfully to steal scenes from Lon Chaney in the role of inscrutable Oriental Li Fang. Most video versions of Flesh and Blood run 55 minutes, and are equipped with a new musical score.