Interstellar opens on Earth in the distant future, as Mother Nature is waging war on humanity. Famine is widespread, and all of mankind's resources are now dedicated to farming in a desperate fight for survival. A former NASA pilot and engineer named Cooper (Matthew McConaughey) has become a homesteader in order to support his teenage son Tom (Timothee Chalamet) and 10-year-old daughter Murph (Mackenzie Foy). Unfortunately, even that begins to look like a futile endeavor after a sandstorm ravages their close-knit community.
Meanwhile, a seemingly supernatural mystery begins to unfold when the "ghost" that dwells in Murph's room sends her a mysterious set of coordinates -- which lead the curious father/daughter duo to a clandestine underground base housing the remnants of NASA. There, renowned physicist Professor Brand (Michael Caine) has been working with a team of astronauts and scientists to find a new planet capable of sustaining human life. Brand quickly persuades Cooper to pilot a mission that will hopefully carry the seeds of human life to a habitable planet in another galaxy. Cooper is soon bound for space with Brand's daughter Amelia (Anne Hathaway) and researchers Doyle (Wes Bentley) and Romilly (David Gyasi).