This 20th Century-Fox programmer stars Anne Baxter and Macdonald Carey as husband and wife, both passengers on an airliner. When the plane develops serious engine trouble, it looks like the end for everyone on board. Certain that he's facing an imminent demise, Carey confesses to Baxter that he's had an affair with her best friend (Catherine McLeod). Baxter mulls over several potential revenges in her mind, casting herself as various famous women of history. The plane lands safely, at which time Baxter learns that the "affair" was nothing more than a discreet flirtation. So much for the 87-minute shaggy dog story which calls itself My Wife's Best Friend.