ISBN-10:
1580539726
ISBN-13:
9781580539722
Pub. Date:
05/31/2006
Publisher:
Artech House, Incorporated
Fundamentals And Applications Of Microfluidics 2nd Ed. / Edition 2

Fundamentals And Applications Of Microfluidics 2nd Ed. / Edition 2

by Nam-Trung Nguyen, Steven T. Wereley
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Overview

Updating the Artech House bestseller, Fundamentals and Applications of Microfluidics, this newly revised second edition provides electrical and mechanical engineers with complete and current coverage of microfluidics - an emerging field involving fluid flow and devices in microscale and nanoscale. The second edition offers a greatly expanded treatment of nanotechnology, electrokinetics and flow theory. The book shows engineers how to take advantage of the performance benefits of microfluidics and serves as an instant reference for state-of-the-art microfluidics technology and applications. The wide range of applications discussed includes fluid control devices, gas and fluid measurement devices, medical testing equipment, and implantable drug pumps. Professionals learn how to choose the best fabrication and enabling technology for a specific microfluidic application.

Product Details

ISBN-13: 9781580539722
Publisher: Artech House, Incorporated
Publication date: 05/31/2006
Series: Artech House Integrated Microsystems Series
Edition description: Second Edition
Pages: 514
Product dimensions: 7.00(w) x 10.00(h) x 1.13(d)

Table of Contents

Prefacexi
Acknowledgmentsxiii
Chapter 1Introduction1
1.1Microfluidics--The Emerging Technology1
1.1.1What Is Microfluidics?1
1.1.2Commercial Aspects4
1.1.3Scientific Aspects6
1.2Milestones of Microfluidics7
1.2.1Device Development7
1.2.2Technology Development8
1.3Organization of the Book9
References10
Chapter 2Fluid Mechanics Theory11
2.1Introduction11
2.1.1Intermolecular Forces13
2.1.2The Three States of Matter15
2.1.3Continuum Assumption16
2.2Continuum Fluid Mechanics at Small Scales20
2.2.1Gas Flows21
2.2.2Liquid Flows27
2.2.3Boundary Conditions29
2.2.4Parallel Flows34
2.2.5Low Reynolds Number Flows40
2.2.6Entrance Effects42
2.2.7Surface Tension45
2.3Molecular Approaches47
2.3.1MD48
2.3.2DSMC Technique51
2.4Electrokinetics53
2.4.1Electro-Osmosis54
2.4.2Electrophoresis57
2.4.3Dielectrophoresis60
2.5Conclusion62
Problems64
References65
Chapter 3Fabrication Techniques for Microfluidics67
3.1Basic Microtechniques67
3.1.1Photolithography67
3.1.2Additive Techniques69
3.1.3Subtractive Techniques78
3.1.4Pattern Transfer Techniques80
3.2Silicon-Based Micromachining Techniques82
3.2.1Silicon Bulk Micromachining82
3.2.2Silicon Surface Micromachining90
3.3Polymer-Based Micromachining Techniques98
3.3.1Thick Resist Lithography98
3.3.2Polymeric Surface Micromachining104
3.3.3Soft Lithography107
3.3.4Microstereo Lithography112
3.3.5Micromolding116
3.4Other Micromachining Techniques118
3.4.1Subtractive Techniques118
3.4.2Additive Techniques121
3.5Assembly and Packaging of Microfluidic Devices122
3.5.1Wafer Level Assembly and Packaging122
3.5.2Device Level Packaging124
3.6Biocompatibility127
3.6.1Material Response128
3.6.2Tissue and Cellular Response128
3.6.3Biocompatibility Tests128
Problems129
References129
Chapter 4Experimental Flow Characterization137
4.1Introduction137
4.1.1Pointwise Methods138
4.1.2Full-Field Methods138
4.2Overview of Micro-PIV144
4.2.1Fundamental Physics Considerations of Micro-PIV144
4.2.2Special Processing Methods for Micro-PIV Recordings155
4.2.3Advanced Processing Methods Suitable for Both Micro/Macro-PIV Recordings160
4.3Micro-PIV Examples163
4.3.1Flow in a Microchannel163
4.3.2Flow in a Micronozzle168
4.3.3Flow Around a Blood Cell171
4.3.4Flow in Microfluidic Biochip173
4.3.5Conclusions175
4.4Extensions of the Micro-PIV technique176
4.4.1Microfluidic Nanoscope176
4.4.2Microparticle Image Thermometry183
4.4.3Infrared Micro-PIV195
4.4.4Particle Tracking Velocimetry197
Problems201
References201
Chapter 5Microfluidics for External Flow Control207
5.1Velocity and Turbulence Measurement207
5.1.1Velocity Sensors208
5.1.2Shear Stress Sensors212
5.2Turbulence Control222
5.2.1Microflaps223
5.2.2Microballoon224
5.2.3Microsynthetic Jet225
5.3Microair Vehicles226
5.3.1Fixed-Wing MAV227
5.3.2Flapping-Wing MAV229
5.3.3Microrotorcraft232
5.3.4Microrockets234
Problems243
References245
Chapter 6Microfluidics for Internal Flow Control: Microvalves247
6.1Design Considerations250
6.1.1Actuators250
6.1.2Valve Spring252
6.1.3Valve Seat253
6.1.4Pressure Compensation Design253
6.2Pneumatic Valves254
6.2.1Pneumatic Actuators254
6.2.2Design Examples255
6.3Thermopneumatic Valves257
6.3.1Thermopneumatic Actuators257
6.3.2Design Examples261
6.4Thermomechanical Valves263
6.4.1Solid-Expansion Valves263
6.4.2Bimetallic Valves264
6.4.3Shape-Memory Alloy Valves268
6.5Piezoelectric Valves271
6.5.1Piezoelectric Actuators271
6.5.2Design Examples273
6.6Electrostatic Valves275
6.6.1Electrostatic Actuators275
6.6.2Design Examples279
6.7Electromagnetic Valves281
6.7.1Electromagnetic Actuators281
6.7.2Design Examples281
6.8Electrochemical Valves283
6.9Capillary-Force Valves285
6.9.1Capillary-Force Actuators285
6.9.2Design Examples288
Problems289
References289
Chapter 7Microfluidics for Internal Flow Control: Micropumps293
7.1Mechanical Pumps295
7.1.1Design Considerations295
7.1.2Check-Valve Pumps297
7.1.3Peristaltic Pumps304
7.1.4Valveless Rectification Pumps308
7.1.5Rotary Pumps313
7.1.6Centrifugal Pumps315
7.1.7Ultrasonic Pumps317
7.2Nonmechanical Pumps318
7.2.1Electrical Pumps318
7.2.2Surface Tension Driven Pumps327
7.2.3Chemical Pumps331
7.2.4Magnetic Pumps332
7.3Scaling Law for Micropumps334
Problems336
References337
Chapter 8Microfluidics for Internal Flow Control: Microflow Sensors343
8.1Nonthermal Flow Sensors345
8.1.1Differential Pressure Flow Sensors345
8.1.2Drag Force Flow Sensors349
8.1.3Lift Force Flow Sensors352
8.1.4Coriolis Flow Sensors352
8.1.5Electrohydrodynamic Flow Sensors353
8.2Thermal Flow Sensors354
8.2.1Design Considerations354
8.2.2Thermoresistive Flow Sensors359
8.2.3Thermocapacitive Flow Sensors363
8.2.4Thermoelectric Flow Sensors364
8.2.5Thermoelectronic Flow Sensors365
8.2.6Pyroelectric Flow Sensors368
8.2.7Frequency Analog Sensors369
Problems369
References370
Chapter 9Microfluidics for Life Sciences and Chemistry373
9.1Microfilters373
9.1.1Design Considerations374
9.1.2Design Examples376
9.2Microneedles379
9.2.1Design Considerations380
9.2.2Design Examples383
9.3Micromixers386
9.3.1Design Considerations389
9.3.2Design Examples394
9.4Microreactors401
9.4.1Design Considerations403
9.4.2Design Examples404
9.5Microdispensers423
9.5.1Design Considerations424
9.5.2Design Examples428
9.6Microseparators434
9.6.1Design Considerations435
9.6.2Gas Chromatography437
9.6.3Liquid Chromatography439
9.6.4Electrophoresis440
Problems442
References445
Appendix AList of Symbols453
Appendix BResources for Microfluidics Research457
Appendix CAbbreviations of Different Plastics459
Appendix DLinear Elastic Deflection Models461
About the Authors463
Index465

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