Pub. Date:
Quintessence Publishing
Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws: History, Etiology, Prevention, and Treatment / Edition 2

Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws: History, Etiology, Prevention, and Treatment / Edition 2


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While many clinicians currently recognize that bisphosphonate usage is associated with osteonecrosis of the jaws, this book establishes the causal relationship between the two, explaining the biologic modes of action that enable bisphosphonates taken both orally and intravenously to induce osteonecrosis of the jaws. Like the first edition, it presents definitive treatment protocols for patients who present at each stage in the progression of osteonecrosis, but this new edition also includes a simplified staging system and information about the serum CTX test for oral bisphosphonate cases. In addition, several management principles and surgical techniques are provided, along with new data on osteopenia and osteoporosis, the conditions for which bisphosphonates are primarily prescribed. The book offers a simple method for predicting risk as well as crucial recommendations for preventing the disease from developing when bisphosphonate therapy is indicated. Comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum. A must-have for the student and practicing clinician alike.

Product Details

ISBN-13: 9780867155105
Publisher: Quintessence Publishing
Publication date: 03/01/2011
Edition description: 2nd Revised ed.
Pages: 150
Product dimensions: 6.70(w) x 9.40(h) x 0.40(d)

About the Author

Robert E. Marx, DDS, professor of surgery and chief of the Division of Oral and Maxillofacial Surgery at the University of Miami Miller School of Medicine, is well known as an educator, researcher, and innovative surgeon. He has pioneered new concepts and treatments for pathologies of the oral and maxillofacial area as well as new techniques in reconstructive surgery. As a researcher, he has made valuable contributions in the use of hyperbaric oxygen following radiation therapy, in the development of plateletrich plasma, and in elucidating the relationships between smoking and carcinogenesis. He also pioneered the clinical applications of recombinant human bone morphogenetic protein and stem cell use and was the first to identify what is now known worldwide as bisphosphonate induced osteonecrosis of the jaws. For the past 34 years, he has overseen the training of scores of residents and fellows, many of whom have themselves established distinguished careers. His many prestigious awards, including the Harry S. Archer Award, the William J. Gies Award, the Paul Bert Award, and the Donald B. Osbon Award, attest to his dedication and commitment to the field of oral and maxillofacial surgery.

Table of Contents


  1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws
  2. 2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family
  3. 3. Medical Indications for Bisphosphonates
  4. 4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws
  5. Risks, Prevention, and Management of Intravenous Bisphosphonate—Induced Osteonecrosis of the Jaws
  6. Risks, Prevention, and Management of Oral Bisphosphonate—Induced Osteonecrosis of the Jaws
  7. Clinical Pathologic Case Samples

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