Hardcover(2 Volume Set)



Completely updated to reflect the latest advances in the field, the 6th Edition of this masterwork encompasses all of today's best knowledge about arthritis and musculoskeletal diseases. A "who's who" of world authorities document the explosion of new information and new developments that have occurred in rheumatology. Coverage progresses from normal joint biology and recent discoveries about immune and inflammatory responses ... through diagnosis and pharmacology ... to the evaluation and management of all of the individual rheumatologic diseases seen in practice. "Continues to dazzle with its remarkable updating and reformatting to reflect the changing scene." (JAMA, review of the last edition)
• 48 of the 115 chapters have been completely rewritten by totally new authors. Others have been extensively revised to present the most state-of-the-art information. An entirely new section thoroughly explores Vasculitic Syndromes.
• A new section on Special Issues features expanded discussions of alternative treatments and chronic pain management. The section onReconstructive Surgery now features the authorship of Dr. Clement B. Sledge.
• Every illustration has been redrawn by a single, outstanding medical illustrator to provide a comprehensible account of all surgical options. The imaging chapter by Dr. Barbara Weissman provides an encyclopedic collection of images on joint pathology.

Product Details

ISBN-13: 9780721680088
Publisher: Elsevier Health Sciences
Publication date: 01/01/1901
Edition description: 2 Volume Set
Pages: 1968
Product dimensions: 9.18(w) x 11.66(h) x 4.19(d)

Table of Contents

Section I: Biology of the Normal Joint
Biology of the Normal Joint
Collagen and Elastin
Matrix Glycoproteins, Proteoglycans, and Cartilage
Proteinases and Matrix Degradation
Biomechanics of Joints
Section II: Immune and Inflammatory Responses
Monocytes, Macrophages, and Dendritic Cells
Immunogenetics of Rheumatic Disease
T Cells
B Cells
Rheumatoid Factors
Antinuclear Antibodies
Immune Complexes
Neutrophils and Eosinophils
Prostaglandins, Leukotrienes, and Related Compounds
Mast Cells
Endothelial Cells and Nitric Oxide
Section III: Evaluation of the Patient
Evidence Based Practice
Examination of the Joints
Monoarticular Arthritis
Polyarticular Arthritis
The Eye
The Skin
Section IV: Musculoskeletal Pain and Evaluation
Fibromyalgia Syndrome
Occupational Musculo-Skeletal Disorders
Sports Medicine
Neck Pain
Shoulder Pain
Low Back Pain
Hip and Knee
Ankle and Foot
Temporomandibular Joint Pain
Hand and Wrist Pian
Section V: Diagnostic Tests and Procedures
Aspiration and Injection of Joints
Synovial Fluid Analysis
Arthroscopy and Synovectomy
Acute Phase Reaction
Biological Markers
Section VI: Special Issues
Psychosocial Management
Alternative/Complementary Therapy
Chronic Pain Management
Outcomes Assessment
Section VII: Clinical Pharmacology
Design of Clinical Trials
Antimalarial Drugs
Gold and Penacillamine
Immunoregulatory Agents
Biological Agents
Section VIII: Rheumatoid Arthritis
Etiology and Pathogenesis
Clinical Features
Therapeutic Strategies
Feltys Syndrome
Sjögrens Syndrome
Section IX: Spondyloarthropathies
Ankylosing Spondylitis
Reiters Syndrome
Psoriatic Arthritis
Enteropathic Arthritis
Section X: SLE and Related Syndromes
Etiology and Pathogenesis
Clinical Manifestations of SLE
Management of SLE
Antiphosholipid Syndrome
Section XI: Vasculitic Syndromes
Giant Cell Arteritis and Polymyalgia Rheumatica
Polyarteritis and Related Disorders
Wegeners Disease and Related Disorders
Hypersensitivity Angiitis
Behçets Disease
Section XII: Scleroderma and Mixed Connective Tissue Diseases
Mixed Connective Tissue Disease
Section XIII: Structure, Function, and Disease of Muscle
Skeletal Muscle
Inflammatory Diseases of Muscle
Section XIV: Rheumatic Diseases of Childhood
Juvenile Rheumatoid Arthritis
SLE, Juvenile Dermatomyositis, Scleroderma and Vasculitis
Section XV: Crystal-Associated Synovitis
Gout and Hyperurecemia
Calcium Pyrophosphate and Hydroxyapatite
Etiology and Pathogenesis of OA
Clinical Features of OA
Management of OA
Heritable Disorders of Structural Proteins
Relapsing Polychondritis
Section XVII: Arthritis Related to Infection
Bacterial Arthritis
Lyme Disease
Mycobacterial and Fungal Infections
Rheumatic Disease and HIV
Viral Arthritis
Rheumatic Fever
Section XVIII: Arthritis Accompanying Systemic Disorders
Iron Storage Disease
Hemophilic Arthropathy
Endocrine and Metabolic Disorders
Hypertrophic Osteoarthropathy
Musculoskeletal Syndromes with Malignancy
Section XIX: Disorders of Bone and Structural Protein
Biology, Physiology, and Morphology of Bone
Osteoporosis and Metabolic Bone Disease
Section XX: Tumors Involving Joints
Tumors and Tumor-like Lesions
Section XXI: Reconstructive Surgery
Introduction to Surgical Management
Principles of Reconstructive Surgery

Appendix I: Guidelines for the Treatment of Rheumatic Disease

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