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Overview

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

*Most comprehensive, up-to-date two-volume set on Vitamin D
*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
*Further sections on emerging uses for treatments of auto-immune diseases and diabetes
*Over 600 illustrations and figures available on CD

Product Details

ISBN-13: 9780080543642
Publisher: Elsevier Science
Publication date: 01/25/2005
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 1952
File size: 53 MB
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About the Author

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.
Dr. Pike’s laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action.

Table of Contents

INTRODUCTION
CH 1: Historical Perspective

SECTION I: CHEMISTRY, METABOLISM, AND CIRCULATION
CH 2: Vitamin D Metabolism
CH 3: Photobiology of Vitamin D
CH 4: The Vitamin D-25 Hydroxylase
CH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase
CH 6: The 25-Hydroxyvitamin D 24-Hydroxylase
CH 7: Mutant Mouse Models of Vitamin D Metabolic Enzymes
CH 8: Vitamin D Binding Protein
CH 9: New Aspects of DBP
CH 10: Endocytic Pathways for 25-(OH) Vitamin D3

SECTION II: MECHANISM OF ACTION
CH 11: The Vitamin D Receptor
CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression
CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions
CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity
CH 15: VDR LBD Crystal Structures
CH 16: Comodulators of VDR-Mediated: Gene Expression
CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex
CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes
CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene
CH 20: Mouse Models of Vitamin D Receptor Ablation
CH 21: Intranuclear Vitamin D Response Element Binding
CH 22: VDR and RXR Subcellular Trafficking
CH 23: 1a,25(OH)2¡Vvitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s)

SECTION III: MINERAL HOMEOSTASIS
CH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview
CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men
CH 26: Phosphate Homeostasis
CH 27: Mineralization
CH 28: Modeling and Remodeling: How Bone Cells Work Together
CH 29: Vitamin D and the Kidney
CH 30: Vitamin D and the Parathyroids
CH 31: Calcium-Sensing Receptor

SECTION IV: TARGET ORGANS AND ACTIONS:
A. Organs/Tissues
CH 32: Bone
CH 33: Cartilage and Vitamin D: Genomic and Nongenomic Regulation
CH 34: Dento-Alveolar Bone Complex and Vitamin D
CH 35: Role in Skin and Hair
CH 36: Regulation of Immune Responses by Vitamin D Receptor Ligands
CH 37: Osteoblasts
CH 38: Vitamin D and Osteoclastogenesis
CH 39: Vitamin D Control of the Calcitonin Gene in Thyroid C Cells
CH 40: Vitamin D Regulation of Type I Collagen Expression in Bone
CH 41: Target Genes: Bone Proteins
CH 42: The Calbindins: Calbindin-D9k and Calbindin-D28k
CH 43: Target Genes
CH 44: Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System
CH 45: Vitamin D and the Cellular Response to Oxidative Stress

SECTION V: HUMAN PHYSIOLOGY
CH 46: Vitamin D: Role in the Calcium Economy
CH 47: Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism
CH 48: Perinatal Vitamin D Actions
CH 49: Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood
CH 50: Vitamin D Metabolism and Aging
CH 51: Vitamin D Metabolism in Pregnancy and Lactation
CH 52: Vitamin D and Reproductive Organs
CH 53: Vitamin D Receptor as a Sensor for Toxic Bile Acids
CH 54: The Renin-Angiotensin System
CH 55: Vitamin D and Muscle
CH 56: Vitamin D and Cardiovascular Medicine

SECTION VI: DIAGNOSIS AND MANAGEMENT
CH 57: Approach to the Patient with Metabolic Bone Disease
CH 58: Detection of Vitamin D and Its Major Metabolites
CH 59: Bone Histomorphometry
CH 60: Radiology of Rickets and Osteomalacia
CH 61: The Pharmacology of Vitamin D, Including Fortification Strategies

SECTION VII: DISORDERS OF THE VITAMIN D: ENDOCRINE SYSTEM
CH 62: How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview
CH 63: Vitamin D and the Pathogenesis of Rickets and Osteomalacia
CH 64: The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D
CH 65: Vitamin D Deficiency and Nutritional Rickets in Children
CH 66: Vitamin D Insufficiency in Adults and the Elderly
CH 67: Vitamin D and Osteoporosis
CH 68: Genetic Vitamin D Receptor Polymorphisms and Risk of
CH 69: Clinical Disorders of Phosphate Homeostasis
CH 70: Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 TIO, ADDR FGF-23
CH 71: Vitamin D Pseudodeficiency
CH 72: Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
CH 73: Glucocorticoids and Vitamin D
CH 74: Drug and Hormone Effects on Vitamin D Metabolism
CH 75: Bone Disorders Associated with Gastrointestinal&Hepatobiliary Disease
CH 76: Vitamin D and Renal Failure
CH 77: Idiopathic Hypercalciuria and Nephrolithiasis
CH 78: Hypercalcemia Due to Vitamin D Toxicity
CH 79: Extra-renal 1„´-hydroxylase Activity and Human Disease

SECTION VIII: NEW VITAMIN D ANALOGS
CH 80: Overview: Rational Design of 1a,25-Dihydroxyvitamin D3 Analogs (Deltanoids)
CH 81: Analog Metabolism
CH 82: Mechanisms for the Selective Actions of Vitamin D Analogs
CH 83: Molecular Basis for Differential Action of Vitamin D Analogs
CH 84: Development of New Vitamin D Analogs
CH 85: Geminis: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains
CH 86: Development of OCT and ED-71
CH 87: 2-Carbon-Modified Analogs of 19-Nor- 1a,25-Dihydroxyvitamin D3
CH 88: Non-steroidal Analogs

SECTION IX: VITAMIN D AND CANCER
CH 89: Vitamin D: Cancer and Differentiation
CH 90: Vitamin D, Sunlight, and the Natural History of Prostate Cancer
CH 91: Epidemiology of Cancer Risk: Vitamin D and Calcium
CH 92: Differentiation and the Cell Cycle
CH 93: Vitamin D and Breast Cancer
CH 94: Vitamin D and Prostate Cancer
CH 95: Vitamin D and Colon Cancer
CH 96: Vitamin D and Hematological: Malignancy
CH 97: Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development

SECTION X: EMERGING USES:
Overview: Vitamin D Vs. Calcium Effects
CH 98: Vitamin D3: Autoimmunity and Immunosuppression
CH 99: Vitamin D and Diabetes
CH 100: Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders
CH 101: Psoriasis and Other Skin Diseases
CH 102: Muscles and Falls
CH 103: Renal Failure and Secondary Hyperparathyroidism
CH 104: Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands

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